L-5-Hydroxytryptophan
- CAS No.
- 4350-09-8
- Chemical Name:
- L-5-Hydroxytryptophan
- Synonyms
- 5-HTP;OXITRIPTAN;(S)-2-Amino-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;L-2-AMINO-3-(5-HYDROXYINDOLYL)PROPIONIC ACID;L-5-HTP;Griffonia seed;5-hydroxy-l-tryptopha;5-Hydroxy-L-tryptophane;L-HTP;quietim
- CBNumber:
- CB9110025
- Molecular Formula:
- C11H12N2O3
- Molecular Weight:
- 220.22
- MDL Number:
- MFCD00064341
- MOL File:
- 4350-09-8.mol
- MSDS File:
- SDS
Melting point | 270 °C (dec.) (lit.) |
---|---|
alpha | -32.5 º (c=1,H2O on dry basis) |
Boiling point | 361.16°C (rough estimate) |
Density | 0.902 g/mL at 25 °C (lit.) |
refractive index |
n |
Flash point | 175 °F |
storage temp. | 2-8°C |
solubility | H2O: 10 mg/mL |
pka | 2.22±0.10(Predicted) |
form | solid |
color | white |
optical activity | [α]22/D 30°, c = 1 in H2O |
Water Solubility | Slightly soluble |
Merck | 14,4847 |
BRN | 88200 |
LogP | -0.140 (est) |
CAS DataBase Reference | 4350-09-8(CAS DataBase Reference) |
FDA UNII | C1LJO185Q9 |
NCI Drug Dictionary | oxitriptan |
ATC code | N06AX01 |
EPA Substance Registry System | L-5-Hydroxytryptophan (4350-09-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS06 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H301 | |||||||||
Precautionary statements | P301+P330+P331+P310 | |||||||||
Hazard Codes | Xn,Xi | |||||||||
Risk Statements | 22-36/37/38-65-20/21/22-20/21 | |||||||||
Safety Statements | 36-26 | |||||||||
RIDADR | UN 2811 6.1/PG 3 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | YN7110000 | |||||||||
F | 3-10 | |||||||||
TSCA | Yes | |||||||||
HazardClass | 6.1 | |||||||||
PackingGroup | III | |||||||||
HS Code | 29339990 | |||||||||
NFPA 704 |
|
L-5-Hydroxytryptophan price More Price(58)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | PHR2597 | 5-Hydroxy-L-tryptophan Pharmaceutical Secondary Standard; Certified Reference Material | 4350-09-8 | 100MG | $267 | 2024-03-01 | Buy |
Sigma-Aldrich | PHL80477 | 5-Hydroxy-L-tryptophan phyproof? Reference Substance | 4350-09-8 | 50MG | $262 | 2024-03-01 | Buy |
Sigma-Aldrich | 1329913 | 5-Hydroxy-L-tryptophan United States Pharmacopeia (USP) Reference Standard | 4350-09-8 | 100mg | $436 | 2024-03-01 | Buy |
Sigma-Aldrich | 107751 | 5-Hydroxy-L-tryptophan 98% (calc. on dried substance) | 4350-09-8 | 1g | $44.4 | 2024-03-01 | Buy |
Sigma-Aldrich | 399698 | 5-Hydroxy-L-tryptophan - CAS 895096 - Calbiochem Serotonin precursor. | 4350-09-8 | 25G | $466 | 2022-05-15 | Buy |
L-5-Hydroxytryptophan Chemical Properties,Uses,Production
Chemical Properties
white to pale grey powder
Uses
5-Hydroxy-L-Tryptophan is a hydroxylated metabolite of L-Tryptophan
Uses
A labelled metabolite of Tryptophan
Uses
5-Hydroxy-L-tryptophan has been used:
- to inject experimental mice for serotonin detection
- as a precursor of 5-hydroxytryptamine and injected in pregnant mice and neonatal rats for vital neutral red staining of lung slices
- as a standard in citrate-acetate buffer for its use in high performance liquid chromatography (HPLC) analysis
Definition
ChEBI: 5-hydroxy-L-tryptophan is the L-enantiomer of 5-hydroxytryptophan. It has a role as a human metabolite, a plant metabolite and a mouse metabolite. It is a 5-hydroxytryptophan, a hydroxy-L-tryptophan and a non-proteinogenic L-alpha-amino acid. It is an enantiomer of a 5-hydroxy-D-tryptophan. It is a tautomer of a 5-hydroxy-L-tryptophan zwitterion.
General Description
Colorless to pale pink crystals.
Air & Water Reactions
L-5-Hydroxytryptophan is sensitive to air. Slightly water soluble .
Reactivity Profile
L-5-Hydroxytryptophan reacts with bases. .
Fire Hazard
Flash point data for L-5-Hydroxytryptophan are not available, however, L-5-Hydroxytryptophan is probably combustible.
Trade name
Levothym (Promonta Lundbeck, Germany), Lévotonine (Panpharma, France), Oxyfan (Coli, Italy), Tript-OH (Sigma- Tai, Italy).
Biochem/physiol Actions
Hydroxylation of L-tryptophan occurs in the brain during serotonin synthesis. This is a step that controls the production of serotonin and also yields 5-hydroxy-l-tryptophan (5-HTP) as a metabolite. Thus, consumption 5-HTP, increases the serotonin level, which might result in depression, lack of sleep and severe headache.
Purification Methods
Likely impurities are 5-hydroxy-D-tryptophan and 5-benzyloxytryptophan. Crystallise 5-hydroxy-L-tryptophan under nitrogen from water by adding EtOH. Store it under nitrogen. Also dissolve it in the minimum volume of hot H2O (~0.7g in 4mL) under nitrogen (charcoal) and allowed it to crystallise at 5o. The picrolonate crystallises from H2O with m 184-186o(dec). [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2732-2737 1961, Morris & Armstrong J Org Chem 22 306 1957, Beilstein 22/14 V 278.]
L-5-Hydroxytryptophan Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Jiangxi Chiyan Biopharmaceutical Technology Co.,Ltd. | +86-18616643091 +86-18616643091 | info@rochipharma.com | China | 246 | 58 |
XI AN SGONEK BIOLOGICAL TECHNOLOGY CO., LTD | 15202951039 | jason@sgonekbio.com | China | 268 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 7190 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50003 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12531 | 58 |
Firsky International Trade (Wuhan) Co., Ltd | +8615387054039 | admin@firsky-cn.com | China | 436 | 58 |
BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 346 | 58 |
Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3002 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21663 | 55 |
View Lastest Price from L-5-Hydroxytryptophan manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-10-10 | L-5-Hydroxytryptophan
4350-09-8
|
US $1.00 / ASSAYS | 1g | 99.99%+ | 20T | Jinan Jianfeng Chemical Co., Ltd | ||
2024-09-27 | L-5-Hydroxytryptophan
4350-09-8
|
US $18.00-206.00 / g | 25g | 0.99 | 100kg | Shanghai UCHEM Inc. | ||
2024-09-18 | L-5-Hydroxytryptophan
4350-09-8
|
US $0.00 / g | 100g | 98.0% | 100kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
- L-5-Hydroxytryptophan
4350-09-8
- US $1.00 / ASSAYS
- 99.99%+
- Jinan Jianfeng Chemical Co., Ltd
- L-5-Hydroxytryptophan
4350-09-8
- US $18.00-206.00 / g
- 0.99
- Shanghai UCHEM Inc.
- L-5-Hydroxytryptophan
4350-09-8
- US $0.00 / g
- 98.0%
- WUHAN FORTUNA CHEMICAL CO., LTD
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